3D Bioplotter Research Papers

Displaying all papers by G. Landberg (1 results)

Breast cancer patient‐derived scaffolds as a tool to monitor chemotherapy responses in human tumor microenvironments

Journal of Cellular Physiology 2021 Volume 236, Issue 6, Pages 4709-4724

Breast cancer is a heterogeneous disease where the tumor microenvironment, including extracellular components, plays a crucial role in tumor progression, potentially modulating treatment response. Different approaches have been used to develop three‐dimensional models able to recapitulate the complexity of the extracellular matrix. Here, we use cell‐free patient‐derived scaffolds (PDSs) generated from breast cancer samples that were recellularized with cancer cell lines as an in vivo‐like culture system for drug testing. We show that PDS cultured MCF7 cancer cells increased their resistance against the front‐line chemotherapy drugs 5‐fluorouracil, doxorubicin and paclitaxel in comparison to traditional two‐dimensional cell cultures. The gene expression…