Biofabrication Industry

→ Bone Regeneration

→ Drug Release

→ Cell/Organ Printing

→ Soft Tissue Fabrication

Proud to Offer the World-Leading 3D Bioprinter —

The biofabrication industry is growing fast and holds the promise of truly improving and saving human lives.

A scaffold for meniscus repair was printed on an EnvisionTEC Manufacturer Series 3D-Bioplotter from a custom tyrosine-derived polymer at the Center for Biomaterials at Rutgers, The State University of New Jersey in collaboration with the Orthopaedic Research Laboratory at Rutgers Biomedical and Health Sciences. This 3D printed implant is currently under commercial development by NovoPedics, Inc.

As such, EnvisionTEC is proud to offer its 3D-Bioplotter in three levels of accessibility — the Starter, Developer and Manufacturer — for the automated production of tissues and organs to address complex health challenges in medicine. Our bioprinter is fueling ongoing medical research around the world, as seen in this sampling of technical papers.

Bioprinting with the 3D-Bioplotter allows medical researchers to combine cells, gels, fibers, polymers, ceramics, metals and more into a single scaffolded object that can replace a diseased, injured or missing body part, from tissue and bone to organs.

In fact, biofabrication research is being done in a wide range of areas:

• skin
• cartilage
• bone
• Blood vessels
• organs such as the heart, kidney, placenta and ovaries
• drug and nutrient delivery

With biofabrication, a platform must be trusted to accurately place cells and mix materials in a sterile, temperature-controlled environment, as the 3D-Bioplotter has been doing for more than a decade. It also should be easy for researchers to use and manipulate for their various research needs.

Dipl. Chem. Carlos Carvalho, process and material development, EnvisionTEC 3D-Bioplotter, a leader in 3D bioprinting.

Dipl. Chem. Carlos Carvalho, Process & Material Development, EnvisionTEC.

“I personally find it fascinating seeing what researchers will do with it next,” said Carlos Carvalho, who led the development of the fourth generation of the 3D-Bioplotter and has worked on the bioprinter since its infancy at the University of Freiburg in Germany. Carvalho cited as an example a 2012 paper about 3D printing graphene that was done with the 3D-Bioplotter as launching an entirely new area of research. The EnvisionTEC bioprinter has also been used to fabricate hyperelastic bone, ovary implants, a placenta model and is being used in bone regeneration research.

With three levels of functionality, this family of printers processes open-source biomaterials using air or mechanical pressure to a syringe, which can fabricate scaffolds to create tissue, organs and more. Our bioprinters are extremely accurate with X-Y repeatability down to 1 μm. All models have been designed for use in a sterile biosafety cabinet, meet standards for clinical trials and offer build sizes up to 192.4 cubic inches.

See how our customers, which includes the U.S. Food and Drug Administration, are using their 3D-Bioplotters below.

Doctors Trust EnvisionTEC

3D Bioprinting with Shah Lab

Northwestern University’s Shah Lab is breaking new ground with EnvisionTEC’s 3D-Bioplotter. 3D printing to help reshape the future and save lives.

The FDA’s Role in Overseeing 3D Printing in Medicine

Learn how the FDA works with 3D printing for innovative research and regulation.

Heart Valve Biofabrication

Demonstration video on how to use EnvisionTEC’s 3D-Bioplotter to create an aorta leaflet heart valve. Showcasing the automatic switching material, software settings and dissolvable support material. Allowing patients with cardiac disease to live happier refreshed lives.

3D Printing a Prosthetic Hand

Witness as our biofabrication expert demonstrates how you can combine EnvisionTEC’s ULTRA 3SP® & 3D-Bioplotter® machines to create a fully functional prosthetic hand.
Models based on

3D Printers for the Biofabrication Industry

The 3D-Bioplotter Manufacturer Series was designed as a tool for advanced tissue engineering and also for use in a production environment. It is the most versatile and advanced of the 3D-Bioplotter options and is capable of utilizing up to 5 materials in a build as well as UV curing capabilities and both heated and cooled platform options.

The 3D-Bioplotter® Developer Series is designed for research groups new to the field of tissue engineering, as well as for specialized use, where limited capability may still meet requirements. It consists of the same basic hardware and software as the Manufacturer Series with reduced functionality regarding camera and park positions.

The 3D-Bioplotter Starter Series is designed for research groups new to the field of tissue engineering with few requirements in parallel material processing and automation. It consists of the same basic hardware and software as the other two 3D-Bioplotter models, but lacks modular capability and platform temperature control. The 3D-Bioplotter Starter Series comes with 2 fixed high-temperature heads.

3D Printing Materials for the Biofabrication Industry

This very versatile material can be used for numerous demo applications: from trying out new shapes and patterns using a cheap material; through making technical parts (e.g. gaskets); to medical device casings

Polycaprolactone (PCL) is one of the most versatile thermoplastic materials for Tissue Engineering Applications. With little thermal degradation, it is an excellent material for large, time-consuming parts.

This sugar derivative can easily be processed as a melt in prolonged jobs with no measurable degradation. The material is biocompatible and cell friendly, ensuring that residue material does not negatively affect the final object’s biological properties.

LT Support RG can easily be processed as a hydrogel in short to medium long jobs. The material is biocompatible and cell friendly, ensuring that residue materials do not negatively affect the final object's biological properties.