3D Bioplotter Research Papers

Displaying all papers about Silicone (11 results)

Silicone resin derived larnite/C scaffolds via 3D printing for potential tumor therapy and bone regeneration

Chemical Engineering Journal 2020 Volume 382, Article 122928

Three dimensional (3D) printing has been used to fabricate bioceramic scaffolds for treating the tumor-related defects in recent years, but the fabrication process and the introduction of anti-tumor agents are still challenging. In this study, porous free carbon-embedding larnite (larnite/C) scaffolds have been successfully fabricated by 3D printing of the silicone resin loaded with CaCO3 filler and high temperature treatment under an inert atmosphere. The fabricated larnite/C scaffolds had uniform interconnected macropores (ca. 400 μm), and exhibited excellent photothermal effect, which was able to kill human osteosarcoma cells (MNNG/HOS) and inhibit the tumor growth in nude mice. Moreover, the larnite/C scaffolds…

Modulation of flexible filaments dynamics due to attachment angle relative to the flow

Experimental Thermal and Fluid Science 2019 Volume 102, Pages 232-244

This paper describes experiments carried out in a wind tunnel with three flexible silicone filaments (length to diameter ratio L/D = 50, 100, 150) hanging in crossflow in the range of reduced velocities of 7 < U* < 150 and at various attachment angles (0 ≤ α ≤ 90°) with respect to the flow direction. At low reduced velocities, due to the negligible bending stiffness, the filaments were statically reconfigured but remained mostly rectilinear along their lengths, except for the relatively small bent portion of the filaments close to the upstream fixed end. As the reduced velocity was further increased the filaments started vibrating, but in...

Fuzzy Evaluation of Rapid Prototyping Methods for Latticed Silicone Pieces

Silicon 2019

In order to compare the influence of the manufacturing methods on the property of silicone samples, the latticed structure of sample are designed, the silicone material is prepared and the silicone sample are produced by 3D printing and injection molding respectively. Four performance indexes of latticed silicone parts including the error of line width, the error of quality, tensile strength at break and elongation at break are proposed and measured. A fuzzy comprehensive evaluation system for evaluating the optimal forming method of the parts is provided. The performance indexes are used as evaluation factors, and the importance degree of the…

Flow-induced motions of flexible filaments hanging in cross-flow

Experimental Thermal and Fluid Science 2018 Volume 97, Pages 254-269

Experiments were carried out to study the dynamics of hanging cantilever flexible filaments in air cross-flow. Thirteen flexible filaments of 0.61 mm diameter and lengths from 20 mm to 60 mm were tested with wind speeds in the range of 1–15 m/s, corresponding to Reynolds numbers of 25 

Determination of the normal fluid load on inclined cylinders from optical measurements of the reconfiguration of flexible filaments in flow

Journal of Fluids and Structures 2018 Volume 76, Pages 488-505

Reconfigured flexible filaments exposed to steady fluid load were investigated using a novel non-contact optical technique to measure the normal fluid force due to the fluid loading on inclined cylinders for Reynolds numbers from 25 to 460: a range not covered in previous studies that is of relevance in drag reduction and energy harvesting applications. The ranges of the buoyancy number and the Cauchy number covered in the tests were 3.6 × 10^4 ≤ B ≤ 2.1 × 10^6 and 7.6 × 10^4 ≤ Ca ≤ 1.4 × 10^7. These newly generated data were then used to assess and extend…

“Tissue Papers” from Organ-Specific Decellularized Extracellular Matrices

Advanced Functional Materials 2017 Volume 27, Article 1700992

Using an innovative, tissue-independent approach to decellularized tissue processing and biomaterial fabrication, the development of a series of “tissue papers” derived from native porcine tissues/organs (heart, kidney, liver, muscle), native bovine tissue/organ (ovary and uterus), and purified bovine Achilles tendon collagen as a control from decellularized extracellular matrix particle ink suspensions cast into molds is described. Each tissue paper type has distinct microstructural characteristics as well as physical and mechanical properties, is capable of absorbing up to 300% of its own weight in liquid, and remains mechanically robust (E = 1–18 MPa) when hydrated; permitting it to be cut, rolled,…

Integrated 3D printed scaffolds and electrical stimulation for enhancing primary human cardiomyocyte cultures

Bioprinting 2017 Volume 6, Pages 18-24

3D printing technology is driving innovation in a wide variety of disciplines, and is beginning to make inroads into the fields of medicine and biology. In particular, 3D printing is being increasingly utilized for the design and fabrication of three-dimensional cell culture scaffolds. This technology allows for scaffolds to be produced rapidly while maintaining a great deal of control over the matrix architecture. This paper presents an effective technique for rapidly designing and fabricating scaffolds from silicone rubber and polycaprolactone (PCL), appropriate for primary human cardiomyocyte cell cultures. Additionally, a stimulation device is developed and presented which can provide 6…

Fabrication of biocompatible enclosures for an electronic implant using 3D printing

International Journal of Rapid Manufacturing 2016 Volume 6, Issue 1, Pages 17-33

A variety of different approaches have been employed to enable implantation of electronic medical microdevices. A novel method of producing low-cost, rapidly fabricated implantable enclosures from biocompatible silicone is presented in this paper. This method utilises 3D computer-aided design software to design and model the enclosures prior to fabrication. The enclosures are then fabricated through additive manufacturing from biocompatible silicone using a 3D bioprinter. In this paper, four different implantable enclosure designs are presented. A prototyping stage with three different prototypes is described, these prototype enclosures are then evaluated through submersion and operation tests. A final design is developed in…

Fabrication of Force Sensor Circuits on Wearable Conductive Textiles

Procedia Technology 2015 Volume 20, Pages 263–269

This paper discusses design and fabrication processes in the development of a wearable and flexible conductive resistive sensor. The design and development of the sensor involve the use of Sn-Ag-Cu (SAC)plated Nylon fabric, precisionfused deposition modeling(FDM) using silicone and petrolatum for etch-resistant masks using the EnvisionTEC GmbH Bioplotter, and wet etching using Chromium, Ammonium Persulphate, and Salt-Vinegar etching solutions. Preliminary testing with other mask types, development processes, and sensor design approaches for various applications are discussed.

3D Printed Biocompatible Enclosures for an Implantable DBS Microdevice

Procedia Technology 2015 Volume 20, Pages 155–161

A number of methods have been used to make electronic medical microdevices biocompatible. This paper presents a novel approach for design and fabrication of biocompatible silicone enclosures for implantable medical microdevices. The approach involves design and formation of a 3D model of the enclosure using a computer-aided design software tool, followed by 3D printing of the enclosures using a bioplotter. Three different implantable enclosure designs are presented. The fabrication of the three enclosures is given. An evaluation of the suitability of the enclosures for implantation of a deep brain stimulation microdevice is discussed through submersion and operation tests. The evaluation…

Desktop manufacturing of complex objects, prototypes and biomedical scaffolds by means of computer-assisted design combined with computer-guided 3D plotting of polymers and reactive oligomers

Macromolecular Materials and Engineering 2000 Volume 282, Issue 1, pages 17-21

Computer-assisted design and image processing were combined with computer-guided one- and two-component air-driven 3D dispensing of hotmelts, solutions, pastes, dispersions of polymers as well as monomers and reactive oligomers to produce solid objects with complex shapes and tailor-made internal structures. During the 3D plotting process either individual microdots or microstrands were positioned in order to construct complex objects, fibers, tubes and scaffolds similar to non-wovens. The resolution was in the range of 200 μm and depended upon inner nozzle diameter, air pressure, plotting speed, rheology, and plotting medium. Plotting in liquid media with densities similar to that of the dispensing…

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