3D Bioplotter Research Papers

Displaying all papers about Humic Acid (1 results)

3D printed, controlled release, tritherapeutic tablet matrix for advanced anti-HIV-1 drug delivery

European Journal of Pharmaceutics and Biopharmaceutics 2019 Volume 138, Pages 99-110

Purpose A 3D-Bioplotter® was employed to 3D print (3DP) a humic acid-polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet comprising of the anti-HIV-1 drugs, efavirenz (EFV), tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC). Methods Chemical interactions, surface morphology and mechanical strength of the FDC were ascertained. In vitro drug release studies were conducted in biorelevant media followed by in vivo study in the large white pigs, in comparison with a market formulation, Atripla®. In vitro-in vivo correlation of results was undertaken. Results EFV, TDF and FTC were successfully entrapped in the 24-layered rectangular prism-shaped 3DP FDC with a…