3D Bioplotter Research Papers

Displaying all papers about Diabetic Patients (1 results)

Decelerated vascularization in tissue-engineered constructs in association with diabetes mellitus in vivo

Journal of Diabetes and its Complications 2015 Volume 29, Issue 7, Pages 855–864

Aims Rapid blood vessel ingrowth in transplanted tissue engineering constructs is the key factor for successful incorporation, but many potential patients who may use engineered tissues suffer from widespread diseases that limit the capacity of neovascularization (e.g. diabetes). Thus, in vivo vascularization analyses of tissue-engineered constructs in angiogenically affected organisms are required. Methods We therefore investigated the in vivo incorporation of collagen-coated and cell-seeded poly-L-lactide-co-glycolide scaffolds in diabetic B6.BKS(D)-Leprdb/J mice using repetitive intravital fluorescence microscopy over a time period of two weeks. For this purpose, scaffolds were seeded with osteoblast-like or bone marrow mesenchymal stem cells and implanted into the…