3D Bioplotter Research Papers

Displaying all papers about Coating (Heparin) (2 results)

Polyester-based ink platform with tunable bioactivity for 3D printing of tissue engineering scaffolds

Biomaterials Science 2019 Volume 7, Pages 560-570

In this work, we synthesized a novel polymeric biomaterial platform with tunable functionalizability for extrusion-based 3D printing. Biodegradable polymers were synthesized using 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (HTy), which is derived from Tyrosol and 2-(4-hydroxyphenyl)acetic acid. p-Phenylenediacetic acid (PDA) was introduced to enhance crystallinity. To enable functionalizability without deteriorating printability, glutamic acid derivatives were introduced into the polymer design, forming copolymers including poly(HTy-co-45%PDA-co-5%Gluhexenamide ester) (HP5GH), poly(HTy-co-45%PDA-co-5%Glupentynamide ester) (HP5GP), and poly(HTy-co-45%PDA-co-5%BocGlu ester) (HP5BG). The resulting polymers have: two melting temperatures (125–131 °C and 141–147 °C), Young’s moduli of 1.9–2.4 GPa, and print temperatures of 170–190 °C. The molecular weight (Mw) loss due to hydrolytic…

Heparin/Poly-L-lysine-coated 3D-printed PLGA scaffolds as drug carriers for local immune modulation in bone regeneration

Society for Biomaterials Annual Meeting and Exposition 2018 Presentation 584

Immune responses after injury play a critical role in bone regeneration. Initiation of inflammation at early stages of repair triggers tissue formation and remodeling; however, uncontrolled inflammation underlies a catabolic effect on tissues as commonly seen in arthritis where inflammation breaks down tissues and hinders regeneration. Our ultimate goal is to design a novel approach on bone scaffolds for which biodegradable scaffolds are loaded with inflammatory cytokines for local immunomodulation as well as bone regeneration. We employed nanoparticles (NPs) composed of heparin (Hep) and poly-L-lysine (PLL) as cytokine drug carriers adhered on 3D-printed poly(lactic-co-glycolic acid) (PLGA) scaffolds. The entire drug…