3D Bioplotter Research Papers

Displaying all papers about Bioactive glass (4 results)

Effect of Polymer Binder on the Synthesis and Properties of 3D-Printable Particle-Based Liquid Materials and Resulting Structures

ACS Omega 2019 Volume 4, Issue 7, Pages 12088-12097

Recent advances have demonstrated the ability to 3D-print, via extrusion, solvent-based liquid materials (previously named 3D-Paints) which solidify nearly instantaneously upon deposition and contain a majority by volume of solid particulate material. In prior work, the dissolved polymer binder which enables this process is a high molecular weight biocompatible elastomer, poly(lactic-co-glycolic) acid (PLGA). We demonstrate in this study an expansion of this solvent-based 3D-Paint system to two additional, less-expensive, and less-specialized polymers, polystyrene (PS) and polyethylene oxide (PEO). The polymer binder used within the 3D-Paint was shown to significantly affect the as-printed and thermal postprocessing behavior of printed structures. This…

3D-printed ternary SiO2CaOP2O5 bioglass-ceramic scaffolds with tunable compositions and properties for bone regeneration

Ceramics International 2019 Volume 45, Issue 8, Pages 10997-11005

Simple ternary SiO2CaOP2O5 bioglasses proved sufficient osteogenesis capacity. In this study, the bioglasses were 3D printed into porous scaffolds and SiO2/CaO molar ratio was altered (from 90/5 to 60/35) to achieve tunable glass-ceramic compositions after thermal treatment. Scaffolds possessed interconnected porous structure with controllable porosities via 3D printing technique. In addition, microstructure and properties of mechanical strength, degradation, ion dissolution and apatite formation were investigated. Characterization results showed that higher content of SiO2 produced more homogeneous crystalline particles and sintering compactness, thus led to higher strength. For scaffolds with higher CaO content, more glasses were maintained and faster degradation rate…

3D Printing Nanoscale Bioactive Glass Scaffolds Enhance Osteoblast Migration and Extramembranous Osteogenesis through Stimulating Immunomodulation

Advanced Healthcare Materials 2018 Volume 7, Article 1800361

Bioactive glass (BG) can repair bone defects, however, it is not clear whether BG has the ability for bone augmentation without making any bone defect. Unlike the intramembranous osteogenesis in bone defect repair, the extramembranous osteogenesis occurs outside the cortical bone and the osteoprogenitor cells show the reversed migration. Herein, nanoscale bioactive glass scaffolds (BGSs) are fabricated, and their role and immunomodulation‐related mechanism in the extramembranous osteogenesis are investigated. The in vitro migration and differentiation of calvaria preosteoblasts are studied by culturing with peripheral macrophage‐conditioned medium after stimulating with BGSs. The results indicate that the proinflammatory environment significantly promotes preosteoblast…

Fabrication and characterization of bioactive glass/alginate composite scaffolds by a self-crosslinking processing for bone regeneration

RSC Advances 2016 Volume 6, Pages 91201-91208

The aim of this study was to synthesize and characterize self-crosslinked bioactive glass/alginate composite scaffolds, as a kind of potential biomaterial for bone regeneration. The scaffolds were fabricated through a self-crosslinking process of alginate by bioactive glass microspheres provided Ca2+ completely, without any organic solvent, crosslinking agent or binder. The microstructure, mechanical properties, apatite-forming ability, ionic release, adhesion, proliferation and ALP activity of human bone marrow-derived mesenchymal stem cells (hBMSCs) of the scaffolds were evaluated. The results showed that uniform films could be obtained on the surface as well as abundant of crosslinking bridges in the interior of scaffolds. The…