3D Bioplotter Research Papers

Displaying all papers by S. Aqueel (1 results)

Development of mechanistic models to identify critical formulation and process variables of pastes for 3D printing of modified release tablets

International Journal of Pharmaceutics 2019 Volume 555, Pages 109-123

The future of pharmaceutical manufacturing may be significantly transformed by 3-dimensional (3D) printing. As an emerging technology, the indicators of quality for materials and processes used in 3D printing have not been fully established. The objective of this study was to identify the critical material attributes of semisolid paste formulations filled into cartridges for 3D printing of personalized medicine. Nineteen semisolid formulations were prepared per a fractional factorial design with three replicates of the center point. The variables investigated included percent loading of API and various soluble and insoluble excipients. Pastes were characterized for viscoelastic characteristics during the 3D printing…