3D Bioplotter Research Papers

Displaying all papers by N. Betancourt (1 results)

Characterization of Cell Damage and Proliferative Ability during and after Bioprinting

ACS Biomaterials Science & Engineering 2018 Volume 4, Issue 11, Pages 3906–3918

When a biomaterial solution containing living cells is subject to bioprinting, the cells experience process-induced stresses, including shear and extensional stresses. These process-induced stresses breach cell membranes and can lead to cell damage, thus reducing cell viability and functioning within the printed constructs. Studies have been conducted to determine the influence of shear stress on cell damage; however, the effect of extensional stress has been typically ignored in the literature until the recently collected evidence of its importance. This paper presents a novel method to characterize and quantify the cell damage caused by both shear and extensional stresses in bioprinting….