3D Bioplotter Research Papers

Displaying all papers by L. C. du Toit (2 results)

3D printed, controlled release, tritherapeutic tablet matrix for advanced anti-HIV-1 drug delivery

European Journal of Pharmaceutics and Biopharmaceutics 2019 Volume 138, Pages 99-110

Purpose A 3D-Bioplotter® was employed to 3D print (3DP) a humic acid-polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet comprising of the anti-HIV-1 drugs, efavirenz (EFV), tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC). Methods Chemical interactions, surface morphology and mechanical strength of the FDC were ascertained. In vitro drug release studies were conducted in biorelevant media followed by in vivo study in the large white pigs, in comparison with a market formulation, Atripla®. In vitro-in vivo correlation of results was undertaken. Results EFV, TDF and FTC were successfully entrapped in the 24-layered rectangular prism-shaped 3DP FDC with a…

A 3D bioprinted in situ conjugated‐co‐fabricated scaffold for potential bone tissue engineering applications

Journal of Biomedical Materials Research A 2018 Volume 106, Issue 5, Pages 1311-1321

There is a demand for progressive approaches in bone tissue engineering to repair and regenerate bone defects resulting from trauma or disease. This investigation sought to engineer a single‐step in situ conjugated polymeric scaffold employing 3D printing technology as an innovative fabricating tool. A polymeric scaffold was engineered in situ employing sodium alginate as a bio‐ink which interacted with a poly(ethyleneimine) solution on bioprinting to form a polyelectrolyte complex through ionic bond formation. Silica gel was included in the bio‐ink as temporal inorganic support component and for ultimate enhancement of osteoinduction. Characterization of the biorelevant properties of the scaffold was…