3D Bioplotter Research Papers

Displaying all papers by J. M. Jukes (1 results)

Critical Steps toward a Tissue-Engineered Cartilage Implant Using Embryonic Stem Cells

Tissue Engineering Part A 2008 Volume: 14 Issue 1, Pages 135-147

Embryonic stem (ES) cells are a potential source for cartilage tissue engineering because they provide an unlimited supply of cells that can be differentiated into chondrocytes. So far, chondrogenic differentiation of both mouse and human ES cells has only been demonstrated in two-dimensional cultures, in pellet cultures, in a hydrogel, or on thin biomaterials. The next challenge will be to form cartilage on a load-bearing, clinically relevant-sized scaffold in vitro and in vivo, to regenerate defects in patients suffering from articular cartilage disorders. For a successful implant, cells have to be seeded efficiently and homogenously throughout the scaffold. Parameters investigated…