3D Bioplotter Research Papers

Displaying all papers by F. Chiellini (1 results)

Multiscale fabrication of biomimetic scaffolds for tympanic membrane tissue engineering

Biofabrication 2015 Volume 7, Number 2, Article 025005

The tympanic membrane (TM) is a thin tissue able to efficiently collect and transmit sound vibrations across the middle ear thanks to the particular orientation of its collagen fibers, radiate on one side and circular on the opposite side. Through the combination of advanced scaffolds and autologous cells, tissue engineering (TE) could offer valuable alternatives to autografting in major TM lesions. In this study, a multiscale approach based on electrospinning (ES) and additive manufacturing (AM) was investigated to fabricate scaffolds, based on FDA approved copolymers, resembling the anatomic features and collagen fiber arrangement of the human TM. A single scale…