3D Bioplotter Research Papers

Displaying all papers by E. J. Chung (1 results)

In situ forming collagen–hyaluronic acid membrane structures: mechanism of self-assembly and applications in regenerative medicine

Acta Biomaterialia 2013 Volume 9, Issue 2, Pages 5153–5161

Bioactive, in situ forming materials have the potential to complement minimally invasive surgical procedures and enhance tissue healing. For such biomaterials to be adopted in the clinic, they must be cost-effective, easily handled by the surgeon and have a history of biocompatibility. To this end, we report a novel and facile self-assembling strategy to create membranes and encapsulating structures using collagen and hyaluronic acid (HA). Unlike membranes built by layer-by-layer deposition of oppositely charged biomolecules, the collagen–HA membranes described here form a diffusion barrier upon electrostatic interaction of the oppositely charged biomolecules, which is further driven by osmotic pressure imbalances….