3D Bioplotter Research Papers

Displaying all papers by C-Y. Liaw (1 results)

Polyester-based ink platform with tunable bioactivity for 3D printing of tissue engineering scaffolds

Biomaterials Science 2019 Volume 7, Pages 560-570

In this work, we synthesized a novel polymeric biomaterial platform with tunable functionalizability for extrusion-based 3D printing. Biodegradable polymers were synthesized using 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (HTy), which is derived from Tyrosol and 2-(4-hydroxyphenyl)acetic acid. p-Phenylenediacetic acid (PDA) was introduced to enhance crystallinity. To enable functionalizability without deteriorating printability, glutamic acid derivatives were introduced into the polymer design, forming copolymers including poly(HTy-co-45%PDA-co-5%Gluhexenamide ester) (HP5GH), poly(HTy-co-45%PDA-co-5%Glupentynamide ester) (HP5GP), and poly(HTy-co-45%PDA-co-5%BocGlu ester) (HP5BG). The resulting polymers have: two melting temperatures (125–131 °C and 141–147 °C), Young’s moduli of 1.9–2.4 GPa, and print temperatures of 170–190 °C. The molecular weight (Mw) loss due to hydrolytic…